Dog Pooping and Peeing Inside?

I have two Beagles, one is eight and the one that is causing the trouble is three. She is peeing and pooing in the house. She has been doing this pretty much her whole life. She is potty trained, but she won't stop going in the house at night and when we are gone to work. We have tried the thunder shirt, kennel, pads, diapers, and all sorts of humane discipline techniques. We let her out around the morning at six, at noon, at three, and also eight. We don't know what else to do.

By james