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Installing HEPA filters on air conditioner or heater vents is not practical or necessary, and may actually increase mite problems. Remember, dust mites cannot survive on the dust in the ducts, and the small holes of the filters will force air out of vents at a higher velocity, stirring up more dust than without filters.
Complete elimination of dust mites is unlikely. Reducing populations is the only likely way to reduce allergens in the air. Reducing humidity in the home by using a dehumidifier may help reduce populations, but reducing humidity levels in microclimates, such as in bed fibers or carpet fibers, is impossible. Chemical control is not necessary, nor will it have a lasting effect on dust mite populations. Regular cleaning and vacuuming will have a greater impact.
About The Author: Source: http://hgic.clemson.edu/factsheets/HGIC2551.htm
Related: 
Getting Rid of Dust Mites
By
08/02/2005
For those of you who are really paranoid and "bugged" about mites on furniture, beds, pillows, rugs, etc., purchase one of those inexpensive portable steamers that use just water and steam those areas. It kills mites deep down. Also, for those of you battling fleas, steam, let dry and vacuum to help with the eggs/larva, even in your pet's sleeping areas. I use it on my cats kitty towers. I love my steam machine! Good for cleaning and sanitizing almost anything!
By Mary Beth, Saginaw MI
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