Not sure if this will work on nail polish, but I just had success removing paint from a shirt using Crisco! I rubbed Crisco into the paint spot and let it sit for a few days. Every day I would scrub the area with a stiff brush and/or would pick the paint with my fingernail. Finally, after about a week, all the paint scraped off. Then I put alcohol-based hand sanitizer on the greasy spot and ran it through the laundry - good as new! I believe the paint was latex and the shirt was cotton. Good luck!
If it is a comforter that you want to keep, I would just take it to a reputable dry-cleaner without trying to clean it yourself. If you botch the job, then it makes it that much harder for the drycleaner to help. It will cost a little more than a home fixit, but a lot less than buying a new comforter.
Not sure if this will work on nail polish, but I just had success removing paint from a shirt using Crisco! I rubbed Crisco into the paint spot and let it sit for a few days. Every day I would scrub the area with a stiff brush and/or would pick the paint with my fingernail. Finally, after about a week, all the paint scraped off. Then I put alcohol-based hand sanitizer on the greasy spot and ran it through the laundry - good as new! I believe the paint was latex and the shirt was cotton. Good luck!
This is obvious but, Nail Polish Remover... assuming it is not an acrylic type of fabric. Acrylic can melt. I am not sure about other synthetic fabrics, but natural ones should be fine.
Editor's Note: Acetone nail polish remover can melt polyester fabrics.
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