I have started replacing sour cream, which has lots of fat and calories, with Greek yogurt. I buy the non-fat Greek yogurt, which has no saturated fat or trans fat, is 110 calories per 6 oz. cup, and has 16 grams of protein. The plain Greek yogurt is great to replace sour cream for baked potatoes, for Mexican dishes, and other things that are added as a condiment as a more nutritional choice for a meal.
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For low fat or fat free sour cream substitute, take 1 cup low fat or fat free cottage cheese, 1/3 cup low fat or skim milk, 1 Tbsp. lemon juice and 1/8 tsp. salt (optional), put into blender and process on medium until smooth. You can add flavoring to this for dips, or chives for a potato topping.