If your kitchen sink is clogged with grease, the best thing I've ever found is Dawn Dishwashing Liquid. I plug the drain and put a huge squirt, maybe 1/2 cup, in the sink. Then I fill the sink with boiling water. Once it's full I pull the plug (use tongs or something, that water is HOT). Let it run down the drain and bingo, clean as a whistle.
Source: From my great friend and sister, Tracy!
By Irishwitch from Aurora, CO
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How do I use Dawn dish washing liquid to unclog a tub?
How do you unclog a drain with Dawn dish washing liquid?