Preheat oven to 350 degrees F. Combine salt, pepper, garlic, and paprika. Rub brisket all over with mixture and place in roasting pan. Mix brown sugar, vinegar, and ketchup in a small bowl; pour over brisket. Lay the onion slices on top of meat. Cover with foil and bake 3-3 1/2 hours or until tender. Slice brisket diagonally across the grain into thin slices. Pour pan juice over and serve.
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